Table 15
Potential Drug/MIBG Interactions
Information Source:
Data from Carlsson et al. (123). Particles were incubated in vitro with 14X-Adr 300 M for
30 minutes at 31 degrees with test drug. Medium also contained glycyl-glycine
buffer ph 7.3 and 2.5 mM ATP and MgC1
Following is a list of drugs that may interfere with the uptake of
metalodobenzylguanidine (MIBG).
Generic names are given with trade names in parenthesis.
Tricyclic antidepressants and related drugs: should not take these 6 weeks prior to test.
Amitriptyline (Elavil, Endep, Etrafon, Triavil, Amitril, Emitrip, Enovil)
Desipramine HCL (Pertoframe, Norpramin)
Doxepin HCL (Adapin, Sinequan)
Imipramine HCL, Pomoate (Tofranil, Imavate, Janimine, Presamine, SK-Pramine,
Tipramine)
Maprotiline HCL (Ludiomil)
Nortriptyline HCL (Aventyl, Pamelor)
Protriptyline HCL (Vivactil)
Trimipramine Maleate (Surmontil)
Trazodone HCL (Desyrel)
Other categories: should be off these medications two weeks prior to test.
Lebetalol (Normodyne, Trandate)
Bretylium Tosylate (Bretylol)
Guanethidine (Ismelin)
Reserpine (Serpasil, Sandril)
Haloperidol (Holdol)
Thiothixene (Navane)
Phenothiazines
Acteophenazine (Tindal)
Carphenazine (Proketazine)
Chlorpromazine (Thorazine, Chloramead, Foypromazine, Promapar)
Fluphenazine (Prolixin, Permitil)
Mesoridazine (Serentil)
Perphenazine (Trilafon)
Piperacteazine (Quide)
Prochlorperzaine (Compazine)
Promazine (Sparome, Norazine, Prozine)
Thioridazine (Meilaril)
Trifluoperazine (Stelazine)
Triflupromazine (Vesprin)
Amphetamines
Amphetamine (Benzedrine, Edrisal, Biphetamine, Dextrosal Amphaplex, Nobese)
Benzphetamine (Didrex)
Chlorphentermine (Pre-Sate) Chlortermine (Voranil)
Dextroamphetamine (Dexedrine, Daro-Tab, Amfedsul, Amsustain, Cendex,
Perke-One, Zamitam, Synatan)
Diethyipropion (Tenuate, Tepanil)
Flenfluramine (Pondimin)
Mazindal (Sanorex)
Methampphetammine (Desoxyn, Methedrine, Methampex)
Methylphenidate (Ritalin)
Phendimetrazine (Plegine)
Phenmetrazine (Preludin)
Phentermine (Wilpo,lonamin)
Nasal Decongestants
Pseudoephedrine HCL (Halofed, Sudafed, Sudrin, Cenafed, Neofed, Dorcol Pediatric
Formula, Neo-Synephrinol Day Relief, Decofed Syrup, Novafed, Cenafed
Syrup, Peedee Dose Decongestant)
Pseudoephedrine Sulfate (Afrinal Repetabs)
Phenylpropanolamine HCL (Also used as an anorexiant) (Propagest, Sucrets Cold
Decongestant Formula, Rhinedecon, Propagest)
Pheynnlephrine HCL (NeopSynephrine, Alconefrin, Rhinall, Allerest Nasal, Doktors
Nose Drops, Nostril, Coricidin Nasal Mist, Sinex, Sinophen, Sinophen,
Sinarest Nasal, Duration Mild)
Most OTC decongestants have either Pseudoephedrine, Phenylephrine or
Pheylpropanolamine. Please check all labels.
"Diet Control Pills"
Pheylpropanolamine HCL (anorexiant) Diadex, Resolution II Half Strength, Prolamine,
Cointrol, Dex-A-Diet, Dexatrim, Unitorl, Acutrim, Appedrine, Grapefruit
Diet Pain with Dladex.
Table 14
Drug Inhibition of Catecholamine Uptake by Adrenal
Medullary Particles
Data
Drug Drug Concentration (M) Percentage Inhibition of
Catecholamine Uptake
| Reserpine |
0.08 |
|
63 |
|
| Segontin |
0.6 |
|
45 |
|
| Mercuric Chloride |
5.0 |
|
95 |
|
Bis-2Oh-benzoic
acid-5-thisosulphonate |
2.7 |
|
40 |
|
| Tetrabenazine |
5 |
|
50 |
|
| Phenoxybenzamine |
16 |
|
55 |
|
| Nylidrin |
20 |
|
50 |
|
| Hermaline |
10 |
|
55 |
|
| Imipramine |
30 |
|
50 |
|
| Desipramine |
30 |
|
25 |
|
Chlorpromazine
(Thorazine) |
20 |
|
50 |
|
p-Chloromercurl
-benzoate |
1000 |
|
100 |
|
| Diethyiosulphonate |
60 |
|
75 |
|
| N-ethymaleimide |
50 |
|
45 |
|
| 5-Hydroxytryptamine |
100 |
|
45 |
|
| Tryptamine |
300 |
|
55 |
|
| Tyramine |
150 |
|
55 |
|
| Cocaine |
1000 |
|
40 |
|
| Bretylium |
500 |
|
10 |
|
| Guanethidine |
800 |
|
15 |
|
| Tranycypromine |
500 |
|
65 |
|
| Dichloroisoprenaline |
350 |
|
60 |
|
|